CHAIX Yves - Tonic Inserm

Yves CHAIX

PU-PH

Physiopathologie des troubles du neuro développement – Principaux axes de recherche

Les troubles du neuro développement et plus spécifiquement les troubles développementaux du langage, de la motricité, et de l’apprentissage chez l’enfant dans un contexte soit primitif, soit secondaire avec pour principal modèle pathologique, la Neurofibromatose de type 1 NF1 (Prévalence 1/3500 naissance). Les objectifs sont d’une part : la compréhension des liens entre les niveaux cognitifs et comportementaux et les dysfonctionnements cérébraux abordés avec les techniques d’imagerie cérébrale fonctionnelle (Potentiels évoqués, IRM fonctionnelle) et d’autre part : l’étude de la comorbidité dans les trouble de l’apprentissage et le rôle des systèmes mnésiques (mémoire de travail, mémoire procédurale et mémoire déclarative).

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Abstracts rédigés ou co-rédigés

> Verbal synchronization to an auditory rhythm is impaired in both DCD and dyslexia but comorbidity does not add learning difficulties
Lê Margaux, Blais Melody, Maziero Stéphanie, Jucla Melanie, Chaix Yves, Tallet Jessica
DCD-14 VANCOUVER 2022
> Discriminating between neurofibromatosis-1 and typically developing children by means of multimodal MRI and multivariate analyses.
F Nemmi, F Cignetti, C Assaiante, S Maziero, F Audic, P Péran, Y Chaix.
5th Congress of the European Academy of Neurology, EAN 2019, 29 juin- 2 Juillet 2019 à Oslo, Norvège.
> Discriminating neurofibromatosis and healthy children with multimodal MRI and machine learning.
F Nemmi, F Cignetti, C Assaiante, S Maziero, F Audic, P Péran, Y Chaix.
Organization for Human Brain Mapping,OHBM 2019, 9-13 juin 2019 à Rome, Italie.
> Atypical attentional cortical activity during resting in teenagers with Developmental Coordination Disorder (DCD): A pilot EEG study.
Desclaux A, Tisseyre J, Albaret J-M, Chaix Y, Tallet J
13th World Congress on Developmental Coordination Disorder DCD13. 5-8th June, University of Jyväskylä, Finland.
> Learning and retention of a temporal sequence in children with Developmental Coordination Disorder depend on the modality (auditory vs visual) of stimulations.
Lê M, Blais M, Maziero, S, Jucla M, Biotteau M, Albaret J-M, Péran P, Chauveau N, Chaix Y, Tallet J
13th World Congress on Developmental Coordination Disorder DCD13. 5-8th June, University of Jyväskylä, Finland.
> Apprentissage déficitaire des communications sociales dans le Trouble Développemental de la Coordination : comorbidité autistique ou conséquence du retard moteur?
Kruck, J., Albaret, J.-M., Krostubiec, V., Chaix, Y. & Biotteau, M.
5ème congrès de la Société Francophone des Troubles d'Apprentissage et du Langage. (SOFTAL) - TOULOUSE
> Structural Neuroimaging in DCD with or without Dyslexia: A contribution to differential diagnosis.
Biotteau, M, Albaret, J.-M, Chauveau, N, & Chaix, Y.
12th International Conference on Children with Developmental Coordination Disorder. FREMANTLE - AUSTRALIE
> Explicit motor learning of a synchronization task is improved by auditory (vs visual) stimulations in children with Developmental Coordination Disorder.
Blais, M, Chaix, Y, Biotteau, M, Maziero, S, Jucla. M, Albaret, J.-M, Péran, P, Tallet J.
12th International Conference on Children with Developmental Coordination Disorder. FREMANTLE - AUSTRALIE
> Combined visuo-spatial and verbal cues improve procedural learning and retention in Developmental Coordination Disorder.
Blais, M, Jucla. M, Maziero, S, Biotteau, M, Albaret, J.-M, Chaix, Y, Tallet J.
12th International Conference on Children with Developmental Coordination Disorder. FREMANTLE - AUSTRALIERésultat de recherche d'images pour "coupe 1er prix"Obtenu le 2ème Prix
> Social communication in Developmental Coordination Disorder and Autism Spectrum Disorder: A shared disability?
Maëlle Biotteau, Jean-Michel Albaret,Vivianne Krostubiec, Yves Chaix & Jeanne Kruck
Congrès Actualité de la recherche en autisme et perspectives d’avenir, CARAPA - TOULOUSE
> Cortical brain structure predicts memory of auditory vs visual rhythmic sequences in Children with and without Developmental Coordination Disorder (DCD).
Blais, M., Péran, P., Chaveau, N., Biotteau, M., Maziero, S., Jucla, M., Albaret, J.-M., Chaix, Y., Tallet, J.
17ème Congrès International de l’Association des Chercheurs en Activités Physiques et Sportives - ACAPS 2017- DIJON
> Déficit procédural et dyslexie : une base explicative à la comorbidité.
Biotteau, M., Albaret, J.-M., & Chaix, Y.
45èmes Entretiens de Médecine Physique et de Réadaptation (EMPR 2017) - MONTPELLIER
> Systèmes mnésiques et Neurofibromatose de type 1 (NF1): un enjeu dans les acquisitions scolaires.
Maziero, S, Blais, M, Biotteau, M, Albaret, J.-M, Barbeau, E, Tallet, J, Jucla, M, Chaix, Y
5ème congrès de la Société Francophone des Troubles d'Apprentissage et du Langage. (SOFTAL) - TOULOUSE
> Inter-hemispheric communication is altered during learning of a new bimanual coordination in teenagers with Developmental Coordination Disorder.
Blais, M, Amarantini, D, Albaret, J.-M, Chaix, Y & Tallet, J.
12th International Conference on Children with Developmental Coordination Disorder. FREMANTLE - AUSTRALIE
> Social communication difficulties in Developmental Coordination Disorder: same or different than those found in Autism Spectrum Disorder (ASD)?
Jeanne Kruck, Jean-Michel Albaret, Vivianne Krostubieck, Yves Chaix, Maëlle Biotteau.
17ème Congrès International de l’Association des Chercheurs en Activités Physiques et Sportives - ACAPS 2017 - DIJON
> Inter-hemispheric communication is altered during learning of a new bimanual coordination in teenagers with developmental coordination disorder
Blais M, Amarantini D, Albaret J-M, Chaix Y, Tallet J
Journée de rentrée école doctorale CLESCO. - TOULOUSE

Publications rédigées ou co-rédigées

> 66- Electro-Clinical Features and Functional Connectivity Analysis in SYN1-Related Epilepsy.
Moya Quiros V, Adham A, Convers P, Lesca G, Mauguiere F, Soulier H, Arzimanoglou A, Bayat A, Braakman H, Camdessanche JP, Casenave P, Chaton L, Chaix Y, Chochoi M, Depienne C, Desportes V, De Ridder J, Dinkelacker V, Gardella E, Kluger GJ, Jung J, Lemesle Martin M, Mancardi MM, Mueller M, Poulat AL, Platzer K, Roubertie A, Stokman MF, Vulto-van Silfhout AT, Wiegand G, Mazzola L.
Ann Neurol. 2024 Aug 23. doi: 10.1002/ana.27063.
> 57- Exploring Memory Systems After Pediatric Posterior Fossa Tumor: From Memory Profile Comparisons in Nonirradiated Versus Irradiated Patients to Episodic Memory Tests Capable of Detecting Radiation-induced Hippocampal Damage.
Baudou E, Pollidoro L, Lemesle B, Maziero S, Tensaouti F, Bertozzi AI, Cazaux M, Costes M, Courbieres N, Dufour C, Grill J, Chaix Y, Pariente J, Laprie A.
Clin Oncol (R Coll Radiol). 2024 Jun 27:S0936-6555(24)00278-4. doi: 10.1016/j.clon.2024.06.054.
> 50- Can neurodevelopmental disorders influence the course of neurodegenerative diseases? A scoping review.
Siguier PLM, Planton M, Baudou E, Chaix Y, Delage A, Rafiq M, Wolfrum M, Gérard F, Jucla M, Pariente J.
Ageing Res Rev. 2024 Jun 8:102354. doi: 10.1016/j.arr.2024.102354.
> 37- Speech disfluencies in children with developmental dyslexia: How do they differ from typical development?
Pistono A, Maziero S, Chaix Y, Jucla M.
Int J Lang Commun Disord. 2024 May-Jun;59(3):1032-1042. doi: 10.1111/1460-6984.12978.
> 30- Motor Adaptation Deficits in Children with Developmental Coordination Disorder and/or Reading Disorder
Jérémy Danna, Margaux Lê, Jessica Tallet, Jean-Michel Albaret, Yves Chaix, Stéphanie Ducrot, Marianne Jover
Children, 2024, 11(4):491. doi:10.3390/children11040491
> 21- A Systematic Review on Visual-Processing Deficits in Neurofibromatosis Type 1: What Possible Impact on Learning to Read?
Vernet M, Ducrot S, Chaix Y.
Dev Neuropsychol. 2024 Mar 12:1-27. doi: 10.1080/87565641.2024.2326151.
> 20- PENDAH program for parents with children with attention deficit hyperactivity disorder. French adaptation of a behavioral parent training group: pilot study.
Marquet-Doleac J, Biotteau M, Tardy M, Broquere M, Marizy E, Faure-Marie N, Lafin N, Dejean S, Chaix Y.
Child Neuropsychol. 2024 Mar 8:1-26. doi: 10.1080/09297049.2024.2326246.
> 4- Behavioral Parent Training for School-Aged Children With ADHD: A Systematic Review of Randomized Control Trials.
Marquet-Doléac, J., Biotteau, M., Chaix, Y.
Journal of Attention Disorders, 28 (3), 377-393, https://doi.org/10870547231211595
> 85- Les habiletés spatiales : évaluations et expressions dans le Trouble Développemental de la Coordination (TDC).
Puyjarinet, F., Tallet, J., Chaix, Y., & Albaret, J.-M.
Les Cahiers Pratiques d’A.N.A.E., 2023, Fascicule N°9, TDC, 33-38.
> 82- Is There a Deficit in Product and Process of Handwriting in Children with Attention Deficit Hyperactivity Disorder? A Systematic Review and Recommendations for Future Research.
Puyjarinet F, Chaix Y, Biotteau M.
Children (Basel). 2023 Dec 27;11(1):31. doi: 10.3390/children11010031.
> 81- The long-term impact of irradiation on functional connectivity in brain circuits involved in memory processes after pediatric posterior fossa tumor.
Baudou E, Peran P, Tensaouti F, Arribarat G, Pariente J, Courbieres N, Pollidoro L, Bertozzi AI, Gambart M, Sevely A, Roques M, Ducassou A, Danna J, Tallet J, Dufour C, Chaix Y, Laprie A.
Radiother Oncol. 2023 Dec 23:110073. doi: 10.1016/j.radonc.2023.110073.
> 71- A Prospective Study of Arterial Spin Labelling in Paediatric Posterior Fossa Tumour Survivors: A Correlation with Neurocognitive Impairment.
Troudi A, Tensaouti F, Cabarrou B, Arribarat G, Pollidoro L, Péran P, Sevely A, Roques M, Chaix Y, Bertozzi AI, Gambart M, Ducassou A, Baudou E, Laprie A.
Clin Oncol (R Coll Radiol). 2023 Sep 29:S0936-6555(23)00339-4. doi: 10.1016/j.clon.2023.09.015.
> 56- Long-term outcomes of paediatric Guillain-Barré syndrome.
Estublier B, Colineaux H, Arnaud C, Cintas P, Baudou E, Chaix Y, Rivier F, Biotteau M, Meyer P, Cheuret E.
Dev Med Child Neurol. 2023 Jul 27. doi: 10.1111/dmcn.15693.
> 23- Impact of a pediatric posterior fossa tumor and its treatments on motor procedural learning.
Baudou E, Danna J, Tallet J, Pollidoro L, Tensaouti F, Bertozzi AI, Pariente J, Courbieres N, Dufour C, Grill J, Chaix Y, Laprie A.
Eur J Paediatr Neurol. 2023 Apr 10;44:37-45. doi: 10.1016/j.ejpn.2023.03.005.
> 88- Developmental dyslexia, developmental coordination disorder and comorbidity discrimination using multimodal structural and functional neuroimaging.
Nemmi F, Cignetti F, Vaugoyeau M, Assaiante C, Chaix Y, Péran P.
Cortex. 2022 Dec 17;160:43-54. doi: 10.1016/j.cortex.2022.10.016.
> 86- A preliminary study of the different memory systems in neurofibromatosis type 1: What is impaired and what is spared?
Mazeiro, S., Jucla, M., Blais, M., Albaret, J.M., Tallet, J., Chaix, Y.
https://doi.org/10.1016/j.braindev.2022.12.002
> 84- The determinants of saccade targeting strategy in neurodevelopmental disorders: The influence of suboptimal reading experience.
Vernet M, Bellocchi S, Danna J, Massendari D, Jover M, Chaix Y, Ducrot S.
Vision Res. 2022 Dec 22;204:108162. doi: 10.1016/j.visres.2022.108162.
> 41- Predicting future poor readers from pre-reading visual skills: A longitudinal study.
Vernet M, Bellocchi S, Leibnitz L, Chaix Y, Ducrot S.
Appl Neuropsychol Child. 2022 Jul-Sep;11(3):480-494. doi: 10.1080/21622965.2021.1895790.
> 32- A review of long-term deficits in memory systems following radiotherapy for pediatric posterior fossa tumor.
Baudou E, Pollidoro L, Iannuzzi S, Bertozzi AI, Tensaouti F, Chaix Y, Laprie A.
Radiother Oncol. 2022 May 28:S0167-8140(22)02278-2. doi: 10.1016/j.radonc.2022.05.022.
> 20- Visual-processing deficits in children with neurofibromatosis type 1: A clinical marker of reading difficulties.
Vernet M, Jover M, Bellocchi S, Maziero S, Jucla M, Tallet J, Danna J, Chaix Y, Ducrot S.
Eur J Paediatr Neurol. 2022 Mar 26;38:25-32. doi: 10.1016/j.ejpn.2022.03.009.
> 13- Atypical connectivity in the cortico-striatal network in NF1 children and its relationship with procedural perceptual-motor learning and motor skills.
Baudou E, Nemmi F, Peran P, Cignetti F, Blais M, Maziero S, Tallet J, Chaix Y.
J Neurodev Disord. 2022 Mar 1;14(1):15. doi: 10.1186/s11689-022-09428-y.
> 90- Specific Cues Can Improve Procedural Learning and Retention in Developmental Coordination Disorder and/or Developmental Dyslexia.
Blais M, Jucla M, Maziero S, Albaret JM, Chaix Y, Tallet J.
Front Hum Neurosci. 2021 Dec 15;15:744562. doi: 10.3389/fnhum.2021.744562.
> 17- Predicting future poor readers from pre-reading visual skills: A longitudinal study.
Vernet M, Bellocchi S, Leibnitz L, Chaix Y, Ducrot S.
Appl Neuropsychol Child. 2021 Mar 17:1-15. doi: 10.1080/21622965.2021.1895790.
> 10- Reading Comprehension Impairment in Children With Neurofibromatosis Type 1 (NF1): The Need of Multimodal Assessment of Attention.
Biotteau M, Tournay E, Baudou E, Destarac S, Iannuzzi S, Faure-Marie N, Castelnau P, Schweitzer E, Rodriguez D, Kemlin I, Dorison N, Rivier F, Carneiro M, Preclaire E, Barbarot S, Lauwers-Cancès V, Chaix Y.
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Voir la publication
J Child Neurol. 2021 Jan 28:883073820981270. doi: 10.1177/0883073820981270.
> 47- Are morphological and structural MRI characteristics related to specific cognitive impairments in neurofibromatosis type 1 (NF1) children?
Baudou E, Nemmi F, Biotteau M, Maziero S, Assaiante C, Cignetti F, Vaugoyeau M, Audic F, Peran P, Chaix Y.
Voir la publication
Eur J Paediatr Neurol. 2020 Jul 31:S1090-3798(20)30144-6. doi: 10.1016/j.ejpn.2020.07.003. Online ahead of print.
> 44- Influence of comorbidity on working memory profile in dyslexia and developmental coordination disorder.
Maziero S, Tallet J, Bellocchi S, Jover M, Chaix Y, Jucla M.
Voir la publication
J Clin Exp Neuropsychol. 2020 Aug 4:1-15. doi: 10.1080/13803395.2020.1798880. Online ahead of print.
> 38- Procedural learning and retention of audio-verbal temporal sequence is altered in children with Developmental Coordination Disorder but cortical thickness matters.
Lê M, Blais M, Jucla M, Chauveau N, Maziero S, Biotteau M, Albaret JM, Péran P, Chaix Y, Tallet J.
Voir la publication
Dev Sci. 2020 Jun 23:e13009. doi: 10.1111/desc.13009.
> 36- The value of screening tests in children with neurofibromatosis type 1 (NF1).
Baudou E, Chaix Y.
Voir la publication
Childs Nerv Syst. 2020 Jun 10. doi: 10.1007/s00381-020-04711-6.
> 31- Sporadic and Familial Variants in NF1: An Explanation of the Wide Variability in Neurocognitive Phenotype?
Biotteau M, Déjean S, Lelong S, Iannuzzi S, Faure-Marie N, Castelnau P, Rivier F, Lauwers-Cancès V, Baudou E, Chaix Y.
Voir la publication
Front Neurol. 2020 May 5;11:368. doi: 10.3389/fneur.2020.00368.
> 51- Developmental coordination disorder.
Biotteau M, Albaret JM, Chaix Y.
Voir la publication
Handb Clin Neurol. 2020;174:3-20. doi: 10.1016/B978-0-444-64148-9.00001-6.
> 24- Discriminating between neurofibromatosis-1 and typically developing children by means of multimodal MRI and multivariate analyses
Nemmi F, Cignetti F, Assaiante C, Maziero S, Audic F, Péran P, Chaix Y
Hum Brain Mapp.
2019;1–14
> 25- Lack of Motor Inhibition as a Marker of Learning Difficulties of Bimanual Coordination in Teenagers With Developmental Coordination Disorder.
Blais M, Baly C, Biotteau M, Albaret JM, Chaix Y, Tallet J.
Dev Neuropsychol. 2017;42(3):207-2019. doi: 10.1080/87565641.2017.1306526.
> 21- Discriminating between neurofibromatosis-1 and typically developing children by means of multimodal MRI and multivariate analyses.
Nemmi F, Cignetti F, Assaiante C, Maziero S, Audic F, Péran P, Chaix Y.
Hum Brain Mapp. 2019 May 11. doi: 10.1002/hbm.24612.
> 60- Paediatric optic neuritis: factors leading to unfavourable outcome and relapses.
Averseng-Peaureaux D, Mizzi M, Colineaux H, Mahieu L, Pera MC, Brassat D, Chaix Y, Berard E, Deiva K, Cheuret E; Kidbiosep study group.
Br J Ophthalmol. 2018 Jun;102(6):808-813. doi: 10.1136/bjophthalmol-2016-309978.
> 43- Brain network connectivity associated with anticipatory postural control in children and adults.
Cignetti F, Vaugoyeau M, Decker LM, Grosbras MH, Girard N, Chaix Y, Péran P, Assaiante C.
Cortex. 2018 Sep 1;108:210-221. doi: 10.1016/j.cortex.2018.08.013.
> 78- Efficacy of an interventional educational programme in mitigating post-traumatic stress in parents who have witnessed a febrile seizure: a pilot before-and-after study.
Frascari F, Dreyfus I, Chaix Y, Tison-Chambellan C.
BMJ Paediatr Open. 2017 Dec 12;1(1):e000107. doi: 10.1136/bmjpo-2017-000107. eCollection 2017.
> 22- Atypical inter-hemispheric communication correlates with altered motor inhibition during learning of a new bimanual coordination pattern in developmental coordination disorder.
Blais M, Amarantini D, Albaret JM, Chaix Y, Tallet J.
Dev Sci. 2017, 2018, 21(3), e12563. doi: 10.1111/desc.12563.
> 59- Neuropsychological status of French children with developmental dyslexia and/or developmental coordination disorder: Are both necessarily worse than one?
Biotteau M, Albaret JM, Lelong S, Chaix Y.
Child Neuropsychol. 2017 May;23(4):422-441. doi: 10.1080/09297049.2015.1127339. Epub 2016 Jan 4.
> 20- Deficit in phonological processes: a characteristic of the neuropsychological profile of children with NF1.
Chaix Y, Lauwers-Cancès V, Faure-Marie N, Gentil C, Lelong S, Schweitzer E, Rodriguez D, Iannuzzi S, Kemlin I, Dorison N, Rivier F, Carniero M, Preclaire E, Barbarot S, Lion-François L, Castelnau P.
Child Neuropsychol. 2017 Apr 10:1-17. doi: 10.1080/09297049.2017.1313970.
> 10- Hallucinations: Etiological analysis of children admitted to a pediatric emergency department.
Vareilles D, Bréhin C, Cortey C, Chevrin AL, Hamon T, Vignes M, Chaix Y, Claudet I.
Arch Pediatr. 2017 Feb 24. pii: S0929-693X(17)30043-X. doi: 10.1016/j.arcped.2017.01.017.
> 66- Neural Signature of DCD: A Critical Review of MRI Neuroimaging Studies.
Biotteau M, Chaix Y, Blais M, Tallet J, Péran P, Albaret JM.
Front Neurol. 2016 Dec 16;7:227. doi: 10.3389/fneur.2016.00227
> Procedural learning and automatization process in children with developmental coordination disorder and/or developmental dyslexia.
Biotteau M, Chaix Y, Albaret JM.
Hum Mov Sci. 2015 Oct;43:78-89. doi: 10.1016/j.humov.2015.07.005.
> 57- Phonological skills, visual attention span, and visual stress in developmental dyslexia.
Saksida A, Iannuzzi S, Bogliotti C, Chaix Y, Démonet JF, Bricout L, Billard C, Nguyen-Morel MA, Le Heuzey MF, Soares-Boucaud I, George F, Ziegler JC, Ramus F.
Dev Psychol. 2016 Oct;52(10):1503-1516.
> 5- What do we really know about motor learning in children with Developmental Coordination Disorder?
Biotteau, M., Chaix, Y., & Albaret, J.-M.
Current Developmental Disorders Report,3(2), (2016) 152-160. doi: 10.1007/s40474-016-0084-8
> 60- Neural changes associated to procedural learning and automatization process in Developmental Coordination Disorder and/or Developmental Dyslexia.
Biotteau M, Péran P, Vayssière N, Tallet J, Albaret JM, Chaix Y.
Eur J Paediatr Neurol. 2016 Aug 12. pii: S1090-3798(16)30135-0. doi: 10.1016/j.ejpn.2016.07.025.
> 37- Systematic MRI in NF1 children under six years of age for the diagnosis of optic pathway gliomas. Study and outcome of a French cohort.
Blanchard G, Lafforgue MP, Lion-François L, Kemlin I, Rodriguez D, Castelnau P, Carneiro M, Meyer P, Rivier F, Barbarot S, Chaix Y; NF France network..
Eur J Paediatr Neurol. 2016 Mar;20(2):275-81. doi: 10.1016/j.ejpn.2015.12.002.
> 32- Motor impairment in children with Neurofibromatosis type 1: Effect of the comorbidity with language disorders.
Iannuzzi S, Albaret JM, Chignac C, Faure-Marie N, Barry I, Karsenty C, Chaix Y.
Brain Dev. 2016 Feb;38(2):181-7. doi: 10.1016/j.braindev.2015.08.001.
> Motor impairment in children with Neurofibromatosis type 1: Effect of the comorbidity with language disorders.
Iannuzzi S, Albaret JM, Chignac C, Faure-Marie N, Barry I, Karsenty C, Chaix Y.
Brain Dev. 2016 Feb;38(2):181-7. doi: 10.1016/j.braindev.2015.08.001.
> 35- Neuropsychological status of French children with developmental dyslexia and/or developmental coordination disorder: Are both necessarily worse than one?
Biotteau M, Albaret JM, Lelong S, Chaix Y.
Child Neuropsychol. 2016 Jan 4:1-20. 74.