TRACER (in the making) / Presentation

Work in progress

Targetable mechanism, Actionable biomarkers, Covert cognition, Early brain injury

Team Leader :  Stein SILVA (PUPH)

Acute brain injury caused by cardiac arrest, ischemic and hemorrhagic strokes are the leading causes of mortality, functional dependence and dementia. Despite significant advances in emerging revascularization strategies, cardiac resuscitation, hemodynamic support, and minimally invasive surgery for intracerebral hemorrhage, a significant proportion of these patients remain at high risk of death and poor functional outcomes. Early and accurate prediction of neurological outcomes is essential for the clinical management of these patients. However, current predictors are only informative for a subset of these patients, leaving up to half of them in a prognostic “gray zone.” Overall, it has been suggested that this insufficient situation is due to the paucity of identification of targetable pathophysiological mechanisms that could support the development and validation of new precision medicine approaches.

The TRACER team aims to improve the management of patients with acute brain injury by using a combination of multidisciplinary methods to provide new robust predictive biomarkers. This will enable innovative risk stratification and prognoses for patients, as well as personalized therapeutic strategies.