Recherche translationnelle en santé,
technologie pour la santé et recherche clinique
Patrice PÉRAN
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- > 1- Iron distribution in the lentiform nucleus: A post-mortem MRI and histology study.Brain Struct Funct. 2021 Jan 2. doi: 10.1007/s00429-020-02175-7.
De Barros A, Arribarat G, Lotterie JA, Dominguez G, Chaynes P, Péran P.
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Publications rédigées ou co-rédigées
PhD
Functional connectivity
The approach: cross-correlation matrix computed from resting session. de Pasquale F, Sabatini U, Della Penna S, Sestieri C, Caravasso CF, Formisano R, Péran P. Neuroimage, 2013
SMA network
Iron brain mapping
Indirect validation: strong correlation between theorical [Fe] and R2* measure
Péran et al., HBM, 2009
Development of high resolution R2* maps using relaxometry
Péran et al., HBM, 2009
The multimodal MRI approach
Methods: Measure of several quantitative parameters
Application in Parkinson’s disease (PD)
MRI PD nigrostriatal signature
-> Able to discriminate PD patients and controls !
Péran et al., Brain, 2010
Neuroimaging & Neuropsychology: Mental representation of action
Healthy subjects
Areas jointly activated by semantics of action and mental representations of action
Péran et al., Brain Res, 2010
Movement disorders diseases
Specific verb impairment in PD patients
Péran et al., Mvt Disord, 2003
Global impairment in HD patients
Péran et al., Mvt Disord, 2004
fMRI in PD patients
Activation maps of positive correlations between each condition and the motor deficit
Péran et al., Cortex, 2009
Péran et al., Brain Lang, 2012