Recherche translationnelle en santé,
technologie pour la santé et recherche clinique
- > Nos équipes de recherche / Equipe DEVIN
- > Equipe DEVIN / Axe 1 : Développement de biomarqueurs en IRM
Travaille sur
- > Effect of Neflamapimod on neuroinflammation using DPA-714 in PET scan in selected Alzheimer disease patients.
Dominique Gouilly, Béatrice Lemesle, Pomies Elsa, Johanne Germain, Pierre Payoux, Mathieu Tafani, Anne-Sophie Brun-Salabert, Claire Thalamas, Marie Benaiteau, Jasmine Carlier, Fabienne Calvas, Patrice Péran, Jérémie Pariente
4th Nuclear Technologies for Health Symposium, 13-14 février 2020, Nantes
- > Multimodal MRI-PET data-driven pipeline for the discrimination of prodromal Alzheimer’s Disease
Federico Nemmi, Pierre Payoux, Jérémie Pariente, Patrice Péran
9th ECCN, 2-3 mars 2020, Parisff
- > Preliminary results : effect of p38α MAPK inhibitor on neuroinflammation assessed by DPA-714 in early Alzheimer disease
Dominique Gouilly , Béatrice Lemesle, Elsa Pomies , Johanne Germain, Pierre Payoux , Mathieu Tafani, Anne-Sophie Brun-Salabert , Claire Thalamas, Marie Benaiteau , Jasmine Carlier, Fabienne Calvas , Patrice Péran , Jérémie Pariente.
8èmes Rencontres de la Fondation Alzheimer, 19-20 novembre 2019, Paris
- > Substantia Nigra locations of iron-content and free-water abnormalities in Parkinson’s Disease.5th Congress of the European Academy of Neurology, EAN 2019, 29 juin- 2 Juillet 2019 à Oslo, Norvège.
Arribarat G, Pasternak O, De Barros A, Galitky M, Rascol O, Péran P.
- > Amyloid imaging in cerebral amyloid angiopathy –related intracerebral haemorrhage and Alzheimer’s disease: a voxel-wise approach.5th Congress of the European Academy of Neurology, EAN 2019, 29 juin- 2 Juillet 2019 à Oslo, Norvège.
Mélanie PLANTON, Laure Saint-Aubert, Nicolas Raposo, Pierre Payoux, Jean-Francois Albucher, Jean Marc Olivot, Patrice Péran, and Jérémie Pariente
- > A whole-brain multimodal discrimination of Parkinsons dDiseas, Multiple System Atrophy and Controls.5th Congress of the European Academy of Neurology, EAN 2019, 29 juin- 2 Juillet 2019 à Oslo, Norvège.
F Nemmi, A Pavy-Le Traon, O Phillips, M Galitzky, W Meissner, O Rascol, P Péran .
- > Discriminating between neurofibromatosis-1 and typically developing children by means of multimodal MRI and multivariate analyses.5th Congress of the European Academy of Neurology, EAN 2019, 29 juin- 2 Juillet 2019 à Oslo, Norvège.
F Nemmi, F Cignetti, C Assaiante, S Maziero, F Audic, P Péran, Y Chaix.
- > Absence of correlation between complaint and visual alterations in PCA patients: A FGD-PET controlled study.5th Congress of the European Academy of Neurology, EAN 2019, 29 juin- 2 Juillet 2019 à Oslo, Norvège.
Guerrier L., Cransac C., Pagès B., Saint-Aubert L., Payoux P.,Péran P., Pariente J.
- > A whole-brain multimodal discrimination of Parkinsons dDiseas, Multiple System Atrophy and Controls.Organization for Human Brain Mapping,OHBM 2019, 9-13 juin 2019 à Rome, Italie.
F Nemmi, A Pavy-Le Traon, O Phillips, M Galitzky, W Meissner, O Rascol, P Péran
- > Discriminating neurofibromatosis and healthy children with multimodal MRI and machine learning.Organization for Human Brain Mapping,OHBM 2019, 9-13 juin 2019 à Rome, Italie.
F Nemmi, F Cignetti, C Assaiante, S Maziero, F Audic, P Péran, Y Chaix.
- > Learning and retention of a temporal sequence in children with Developmental Coordination Disorder depend on the modality (auditory vs visual) of stimulations.13th World Congress on Developmental Coordination Disorder DCD13. 5-8th June, University of Jyväskylä, Finland.
Lê M, Blais M, Maziero, S, Jucla M, Biotteau M, Albaret J-M, Péran P, Chauveau N, Chaix Y, Tallet J
- > Amélioration de la relaxométrie R2* avec la prise en compte d’une composante bi-compartimentale.4ème Congrès de la Société Française de Résonance Magnétique en Biologie & Médecine - SFRMBM 2019 - 19-21 Mars 2019 à Strasbourg.
Michaud M., Arribarat G., Boucher S., Péran P.
- > Optimisation de l’acquisition IRM multiparamétrique dédiée au Tronc Cérébral.4ème Congrès de la Société Française de Résonance Magnétique en Biologie & Médecine - SFRMBM 2019 - 19-21 Mars 2019 à Strasbourg.
Arribarat, G., De Barros, A., Michaud, M., Favé, Y., Gros-Dagnac, H,. Lotterie, J-A., Péran, P.
- > Correlation between glucose metabolism and visual complaint in posterior cortical atrophy. A FGD-PET study.Réunion Francophone sur la Maladie d’Alzheimer & les Syndrome Apparentés (RFMASA). 11-14 Juin 2018, Lille, France.
Guerrier L., Cransac C., Pagès B., Saint-Aubert L., Péran P., Pariente J.
- > Longitudinal changes of R2 star and diffusion parameters in substantia nigra of Parkinson’s disease patients.8th European Conference onClinical Neuroimaging, 20-21 Mai 2018, Bruxelles, Belgique.
G.Arribarat, O. Pasternak, O. Rascol, P. Péran.
- > Functional connectivity changes in resting state MRI after donepezil treatment in healthy participants8th European Conference onClinical Neuroimaging, 20-21 Mai 2018, Bruxelles, Belgique.
P Péran, A.-S Salabert, T. Dondaine, J. Sein, J.A. Gutierrez, X. Leclerc, H. Gros-Dagnac, J Llido, J.-P. Ranjeva, R. Lopes, L. Lanteaume, O. Blin, C Thalamas, R Bordet, P Payoux, PharmaCog Consortium
- > Application de la théorie des graphes dans l’exploration des réseaux cérébraux au cours du coma4e Rencontre " Objectif ESOF (EuroScience Open Forum) 2018" - TOULOUSE
Brigitta Malagurski, Patrice Péran, Stein Silva.
- > Explicit motor learning of a synchronization task is improved by auditory (vs visual) stimulations in children with Developmental Coordination Disorder.12th International Conference on Children with Developmental Coordination Disorder. FREMANTLE - AUSTRALIE
Blais, M, Chaix, Y, Biotteau, M, Maziero, S, Jucla. M, Albaret, J.-M, Péran, P, Tallet J.
- > Cortical brain structure predicts memory of auditory vs visual rhythmic sequences in Children with and without Developmental Coordination Disorder (DCD).17ème Congrès International de l’Association des Chercheurs en Activités Physiques et Sportives - ACAPS 2017- DIJON
Blais, M., Péran, P., Chaveau, N., Biotteau, M., Maziero, S., Jucla, M., Albaret, J.-M., Chaix, Y., Tallet, J.
- > MR imaging predictor of survival in pediatric ependymoma patients after radiotherapyEuropean SocieTy for Radiotherapy and Oncology (ESTRO) - VIENNE
F. Tensaouti, A. Ducassou, L. Chaltiel, A. Sevely, S. Bolle, X. Muracciole, B. Coche-Dequant, C. Alapetite, S. Supiot, A. Huchet,V. Bernier, L. Claude, A.I. Bertozzi-Salamon, P. Péran, P. Payoux, A. Laprie.
- > Cortex cingulaire et anosognosie dans la Maladie d’Alzheimer : étude en imagerie multimodale41ièmes Journées de Printempsde SNLF - GRENOBLE Obtenu Prix de la meilleure communication orale
Laura Guerrier, Johanne Le Men, Anaïs Gane, Mélanie Planton, Anne-Sophie Salabert, Pierre Payoux, Hervé Dumas, Fabrice Bonneville, Patrice Péran, Jérémie Pariente
- > Diffusion tensor imaging of white matter tracts in the normal equidae brainEAVA (European Association of Veterinary Anatomists) - VIENNE
F. Labelle, G. Arribarat, S. Monteil, S. Ken, F. Audigie, H. Gros, JP. Desirat, P. Peran, A. Deviers, G. Mogicato
- > Spontaneous posteromedial voxel-based connection density in comatose patientsOHBM (Organization for Human Brain Mapping) - GENEVE
Brigitta Malagurski, Patrice Péran, Stein Silva
- > Approche IRM multimodale du tronc cérébralJournées Nationales du Réseau Doctoral en Micro-nanoélectronique - TOULOUSE
Germain Arribarat, Patrice Péran
- > Anatomy of the normal equine brain: a cross-sectional and 3T magnetic resonance imaging comparative study Obtenu le PRIX SIMIC-GRAUEAVA (European Association of Veterinary Anatomists) - VIENNE
Sophie Monteil, Fabrice Audigie, Hélène Gros, Patrice Peran, Sophie Pradier, Alexandra Deviers and Giovanni Mogicato
- > Medial thalamic stroke and its impact on familiarity and recollection.1-BNS-SNLF, British and French Neuropsychological Societies - LONDRES 2-6th International Conference on Memory (ICOM-6) - BUDAPEST
Lola Danet, Jérémie Pariente, Pierre Eustache, Nicolas Raposo, Igor Sibon, Jean-François Albucher, Fabrice Bonneville, Patrice Peran, Emmanuel J.Barbeau
Abstracts rédigés ou co-rédigés
- > 16- Atypical clinical presentation and typical FTD atrophy: 17-year clinical follow-up and MRI analysis of a slowly progressive bvFTD associated with C9orf72 expansion.Rev Neurol (Paris). 2020 Mar 13. pii: S0035-3787(20)30394-5. doi: 10.1016/j.neurol.2020.02.003.
Géraudie A, Guerrier L, Le Ber I, Clot F, Péran P, Pariente J.
- > 9- Neuromelanin Locus Coeruleus MRI Contrast in Migraine With Aura.Headache. 2020 Feb 17. doi: 10.1111/head.13771.
Gollion C, Arribarat G, Ruidavets JB, Fabre N, Barège M, Bonneville F, Larrue V, Peran P.
- > 8- Quantitative MRI markers in Parkinson’s disease and parkinsonian syndromes.Curr Opin Neurol. 2020 Feb 11. doi: 10.1097/WCO.0000000000000796.
Arribarat G, Péran P.
- > 1- Florbetapir Regional Distribution in Cerebral Amyloid Angiopathy and Alzheimer’s Disease: A PET Study.J Alzheimers Dis. 2020 Jan 13. doi: 10.3233/JAD-190625.
Planton M, Saint-Aubert L, Raposo N, Payoux P, Salabert AS, Albucher JF, Olivot JM, Péran P, Pariente J.
- > 53- Multiple System Atrophy: Recent Developments and Future PerspectivesMov Disord. 2019 Nov 6. doi: 10.1002/mds.27894.
Meissner WG, Fernagut PO, Dehay B, Péran P, Traon AP, Foubert-Samier A, Lopez Cuina M, Bezard E, Tison F, Rascol O.
- > 51- Posterior Cortical Atrophy: Does Complaint Match the Impairment? A Neuropsychological and FDG-PET StudyFront Neurol. 2019 Sep 20;10:1010. doi: 10.3389/fneur.2019.01010.
Guerrier L, Cransac C, Pages B, Saint-Aubert L, Payoux P, Péran P, Pariente J
- > 50- Significant Decrease in Hippocampus and Amygdala Mean Diffusivity in Treatment-Resistant Depression Patients Who Respond to Electroconvulsive Therapy. Yrondi A, Nemmi F, Billoux S, Giron A, Sporer M, Taib S, Salles J, Pierre D, Thalamas C, Schmitt L, Péran P, Arbus C. Front Psychiatry. 2019 Sep 19;10:694. doi: 10.3389/fpsyt.2019.00694.
- > 44- Grey Matter changes in treatment-resistant depression during electroconvulsive therapy.J Affect Disord. 2019 Jul 31;258:42-49. doi: 10.1016/j.jad.2019.07.075.
Yrondi A, Nemmi F, Billoux S, Giron A, Sporer M, Taib S, Salles J, Pierre D, Thalamas C, Rigal E, Danet L, Pariente J, Schmitt L, Arbus C, Péran P.
- > 42- Enlarged perivascular spaces and florbetapir uptake in patients with intracerebral hemorrhage.Eur J Nucl Med Mol Imaging. 2019 Jul 29. doi: 10.1007/s00259-019-04441-1.
Raposo N, Planton M, Payoux P, Péran P, Albucher JF, Calviere L, Viguier A, Rousseau V, Hitzel A, Chollet F, Olivot JM, Bonneville F, Pariente J.
- > 25- A totally data-driven whole-brain multimodal pipeline for the discrimination of Parkinson’s disease, multiple system atrophy and healthy controlNeuroImage Clinical
Nemmi F, Pavy-Le Traon A, Phillips O.R, Galitzky M, Meissner W.G, Rascol O, Péran P
- > 30- Substantia nigra locations of iron-content, free-water and mean diffusivity abnormalities in moderate stage Parkinson’s disease.Parkinsonism Relat Disord. 2019 May 22. pii: S1353-8020(19)30254-8. doi: 10.1016/j.parkreldis.2019.05.033.
Arribarat G, Pasternak O, De Barros A, Galitzky M, Rascol O, Péran P.
- > 24- Discriminating between neurofibromatosis-1 and typically developing children by means of multimodal MRI and multivariate analyses2019;1–14
Nemmi F, Cignetti F, Assaiante C, Maziero S, Audic F, Péran P, Chaix Y Hum Brain Mapp.
- > 21- Discriminating between neurofibromatosis-1 and typically developing children by means of multimodal MRI and multivariate analyses.Hum Brain Mapp. 2019 May 11. doi: 10.1002/hbm.24612.
Nemmi F, Cignetti F, Assaiante C, Maziero S, Audic F, Péran P, Chaix Y.
- > 15- Topological disintegration of resting state functional connectomes in coma.Neuroimage. 2019 Mar 9. pii: S1053-8119(19)30185-5. doi: 10.1016/j.neuroimage.2019.03.012.
Malagurski B, Péran P, Sarton B, Vinour H, Naboulsi E, Riu B, Bounes F, Seguin T, Lotterie JA, Fourcade O, Minville V, Ferré F, Achard S, Silva S.
- > 43- Brain network connectivity associated with anticipatory postural control in children and adults.Cortex. 2018 Sep 1;108:210-221. doi: 10.1016/j.cortex.2018.08.013.
Cignetti F, Vaugoyeau M, Decker LM, Grosbras MH, Girard N, Chaix Y, Péran P, Assaiante C.
- > 24- Impact of spontaneous intracerebral hemorrhage on cognitive functioning: An update.Rev Neurol (Paris). 2017 Jul - Aug;173(7-8):481-489. doi: 10.1016/j.neurol.2017.06.010. Epub 2017 Aug 31. Review.
Planton M, Raposo N, Danet L, Albucher JF, Péran P, Pariente J.
- > 38- Assessment of Translocator Protein Density, as Marker of Neuroinflammation, in Major Depressive Disorder: A Pilot, Multicenter, Comparative, Controlled, Brain PET Study (INFLADEP Study).Front Psychiatry. 2018 Jul 24;9:326. doi: 10.3389/fpsyt.2018.00326. eCollection 2018.
Yrondi A, Aouizerate B, El-Hage W, Moliere F, Thalamas C, Delcourt N, Sporer M, Taib S, Schmitt L, Arlicot N, Meligne D, Sommet A, Salabert AS, Guillaume S, Courtet P, Galtier F, Mariano-Goulart D, Champfleur NM, Bars EL, Desmidt T, Lemaire M, Camus V, Santiago-Ribeiro MJ, Cottier JP, Fernandez P, Meyer M, Dousset V, Doumy O, Delhaye D, Capuron L, Leboyer M, Haffen E, Péran P, Payoux P, Arbus C.
- > 37- Involvement of the Cingulate Cortex in Anosognosia: A Multimodal Neuroimaging Study in Alzheimer’s Disease Patients.J Alzheimers Dis. 2018 Jul 20. doi: 10.3233/JAD-180324.
Guerrier L, Men JL, Gane A, Planton M, Salabert AS, Payoux P, Dumas H, Bonneville F, Péran P, Pariente J.
- > 51- Imaging biomarkers of outcome after radiotherapy for pediatric ependymoma.Radiother Oncol. 2018 Apr;127(1):103-107. doi: 10.1016/j.radonc.2018.02.008.
Tensaouti F, Ducassou A, Chaltiel L, Sevely A, Bolle S, Padovani L, Jouin A, Alapetite C, Supiot S, Huchet A, Bernier V, Claude L, Kerr C, Le Prisé E, Bertozzi-Salamon AI, Liceaga S, Lotterie JA, Péran P, Laprie A; French Society for Childhood Cancer (SFCE).
- > 8- Imaging biomarkers of outcome after radiotherapy for pediatric ependymoma.French Society for Childhood Cancer (SFCE). Radiother Oncol. 2018 Feb 27. pii: S0167-8140(18)30064-1. doi: 10.1016/j.radonc.2018.02.008.
Tensaouti F, Ducassou A, Chaltiel L, Sevely A, Bolle S, Padovani L, Jouin A, Alapetite C, Supiot S, Huchet A, Bernier V, Claude L, Kerr C, Le Prisé E, Bertozzi-Salamon AI, Liceaga S, Lotterie JA, Péran P, Laprie A;
- > 5- MRI supervised and unsupervised classification of Parkinson’s disease and multiple system atrophy.Mov Disord. 2018 Feb 23. doi: 10.1002/mds.27307.
Péran P, Barbagallo G, Nemmi F, Sierra M, Galitzky M, Traon AP, Payoux P, Meissner WG, Rascol O.
- > 57- Electroconvulsive therapy, depression, the immune system and inflammation: A systematic review.Brain Stimul. 2017 Oct 19. pii: S1935-861X(17)30946-4. doi: 10.1016/j.brs.2017.10.013.
Yrondi A, Sporer M, Péran P, Schmitt L, Arbus C, Sauvaget A.
- > 42- Medial thalamic stroke and its impact on familiarity and recollection.Elife. 2017 Aug 24;6. pii: e28141. doi: 10.7554/eLife.28141.
Danet L, Pariente J, Eustache P, Raposo N, Sibon I, Albucher JF, Bonneville F, Péran P, Barbeau EJ.
- > 42- Medial thalamic stroke and its impact on familiarity and recollection.Elife. 2017 Aug 24;6. pii: e28141. doi: 10.7554/eLife.28141.
Danet L, Pariente J, Eustache P, Raposo N, Sibon I, Albucher JF, Bonneville F, Péran P, Barbeau EJ.
- > 43- Impact of spontaneous intracerebral hemorrhage on cognitive functioning: An update.2017 Aug 21. pii: S0035-3787(17)30543-X. doi: 10.1016/j.neurol.2017.06.010.
Planton M, Raposo N, Danet L, Albucher JF, Péran P, Pariente J. Rev Neurol (Paris).
- > 38- Florbetapir imaging in cerebral amyloid angiopathy-related hemorrhages.Neurology. 2017 Jul 19. pii: 10.1212/WNL.0000000000004228. doi: 10.1212/WNL.0000000000004228.
Raposo N, Planton M, Péran P, Payoux P, Bonneville F, Lyoubi A, Albucher JF, Acket B, Salabert AS, Olivot JM, Hitzel A, Chollet F, Pariente J.
- > 29- The anatomical scaffold underlying the functional centrality of known cortical hubs.Hum Brain Mapp. 2017 Jul 6. doi: 10.1002/hbm.23721.
de Pasquale F, Della Penna S, Sabatini U, Caravasso Falletta C, Peran P.
- > 27- High prevalence of cognitive impairment after intracerebral hemorrhage.PLoS One. 2017 Jun 1;12(6):e0178886. doi: 10.1371/journal.pone.0178886. eCollection 2017.
Planton M, Saint-Aubert L, Raposo N, Branchu L, Lyoubi A, Bonneville F, Albucher JF, Olivot JM, Péran P, Pariente J.
- > 26- Neural signature of coma revealed by posteromedial cortex connection density analysis.Neuroimage Clin. 2017 May 6;15:315-324. doi: 10.1016/j.nicl.2017.03.017. eCollection 2017.
Malagurski B, Péran P, Sarton B, Riu B, Gonzalez L, Vardon-Bounes F, Seguin T, Geeraerts T, Fourcade O, de Pasquale F, Silva S.
- > 10- How specialized are writing-specific brain regions? An fMRI study of writing, drawing and oral spelling.Cortex. 2016 Dec 18;88:66-80. doi: 10.1016/j.cortex.2016.11.018.
Planton S, Longcamp M, Péran P, Démonet JF, Jucla M.
- > 66- Neural Signature of DCD: A Critical Review of MRI Neuroimaging Studies.Front Neurol. 2016 Dec 16;7:227. doi: 10.3389/fneur.2016.00227
Biotteau M, Chaix Y, Blais M, Tallet J, Péran P, Albaret JM.
- > 41- Identification of a candidate biomarker from perfusion MRI to anticipate glioblastoma progression after chemoradiation.Eur Radiol. 2016 Nov;26(11):4194-4203.
Khalifa J, Tensaouti F, Chaltiel L, Lotterie JA, Catalaa I, Sunyach MP, Ibarrola D, Noël G, Truc G, Walker P, Magné N, Charissoux M, Ken S, Peran P, Berry I, Moyal EC, Laprie A.
- > 64- Structural-functional brain changes in depressed patients during and after electroconvulsive therapy.Acta Neuropsychiatr. 2016 Nov 23:1-12.
Yrondi A, Péran P, Sauvaget A, Schmitt L, Arbus C.
- > 53- Prognostic and predictive values of diffusion and perfusion MRI in paediatric intracranial ependymomas in a large national study.Br J Radiol. 2016 Oct;89(1066):20160537. doi: 10.1259/bjr.20160537.
Tensaouti F, Ducassou A, Chaltiel L, Sevely A, Bolle S, Muracciole X, Coche-Dequant B, Alapetite C, Supiot S, Huchet A, Bernier V, Claude L, Bertozzi-Salamon AI, Liceaga S, Lotterie JA, Péran P, Payoux P, Laprie A; radiotherapy committee of the French Society for Childhood Cancer (SFCE)..
- > 59- Do perfusion and diffusion MRI predict glioblastoma relapse sites following chemoradiation?J Neurooncol. 2016 Oct;130(1):181-192.
Khalifa J, Tensaouti F, Lotterie JA, Catalaa I, Chaltiel L, Benouaich-Amiel A, Gomez-Roca C, Noël G, Truc G, Péran P, Berry I, Sunyach MP, Charissoux M, Johnson C, Cohen-Jonathan Moyal E, Laprie A.
- > 39- Multimodal Magnetic Resonance Imaging in Alzheimer’s Disease Patients at Prodromal Stage.J Alzheimers Dis. 2016;50(4):1035-50. doi: 10.3233/JAD-150353.
Eustache P, Nemmi F, Saint-Aubert L, Pariente J, Péran P.
- > 60- Neural changes associated to procedural learning and automatization process in Developmental Coordination Disorder and/or Developmental Dyslexia.Eur J Paediatr Neurol. 2016 Aug 12. pii: S1090-3798(16)30135-0. doi: 10.1016/j.ejpn.2016.07.025.
Biotteau M, Péran P, Vayssière N, Tallet J, Albaret JM, Chaix Y.
- > 34- Multimodal MRI assessment of nigro-striatal pathway in multiple system atrophy and Parkinson disease.Mov Disord. 2016 Mar;31(3):325-34. doi: 10.1002/mds.26471.
Barbagallo G, Sierra-Peña M, Nemmi F, Traon AP, Meissner WG, Rascol O, Péran P.
- > Thalamic amnesia after infarct: The role of the mammillothalamic tract and mediodorsal nucleus.Neurology. 2015 Dec 15;85(24):2107-15. doi: 10.1212/WNL.0000000000002226.
Danet L, Barbeau EJ, Eustache P, Planton M, Raposo N, Sibon I, Albucher JF, Bonneville F, Peran P, Pariente J.
- > Disruption of posteromedial large-scale neural communication predicts recovery from coma.Neurology. 2015 Dec 8;85(23):2036-44. doi: 10.1212/WNL.0000000000002196.
Silva S, de Pasquale F, Vuillaume C, Riu B, Loubinoux I, Geeraerts T, Seguin T, Bounes V, Fourcade O, Demonet JF, Péran P.
- > Voxel-based evidence of perfusion normalization in glioblastoma patients included in a phase I-II trial of radiotherapy/tipifarnib combination.J Neurooncol. 2015 Sep;124(3):465-73. doi: 10.1007/s11060-015-1860-8.
Ken S, Deviers A, Filleron T, Catalaa I, Lotterie JA, Khalifa J, Lubrano V, Berry I, Péran P, Celsis P, Moyal EC, Laprie A.
- > Parkinson’s disease and local atrophy in subcortical nuclei: insight from shape analysis.Neurobiol Aging. 2015 Jan;36(1):424-33. doi: 10.1016/j.neurobiolaging.2014.07.010.
Nemmi F, Sabatini U, Rascol O, Péran P.
- > Insight on AV-45 binding in white and grey matter from histogram analysis: a study on early Alzheimer’s disease patients and healthy subjects.Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1408-18. doi: 10.1007/s00259-014-2728-4.
Nemmi F, Saint-Aubert L, Adel D, Salabert AS, Pariente J, Barbeau EJ, Payoux P, Péran P.
- > Comparison between PET template-based method and MRI-based method for cortical quantification of florbetapir (AV-45) uptake in vivo.Eur J Nucl Med Mol Imaging. 2014 May;41(5):836-43. doi: 10.1007/s00259-013-2656-8.
Saint-Aubert L, Nemmi F, Péran P, Barbeau EJ, Payoux P, Chollet F, Pariente J.
Publications rédigées ou co-rédigées
Functional connectivity
The approach: cross-correlation matrix computed from resting session. de Pasquale F, Sabatini U, Della Penna S, Sestieri C, Caravasso CF, Formisano R, Péran P. Neuroimage, 2013
SMA network
Iron brain mapping
Indirect validation: strong correlation between theorical [Fe] and R2* measure
Péran et al., HBM, 2009
Development of high resolution R2* maps using relaxometry
Péran et al., HBM, 2009
The multimodal MRI approach
Methods: Measure of several quantitative parameters
Application in Parkinson’s disease (PD)
MRI PD nigrostriatal signature
-> Able to discriminate PD patients and controls !
Péran et al., Brain, 2010
Neuroimaging & Neuropsychology: Mental representation of action
Healthy subjects
Areas jointly activated by semantics of action and mental representations of action
Péran et al., Brain Res, 2010
Movement disorders diseases
Specific verb impairment in PD patients
Péran et al., Mvt Disord, 2003
Global impairment in HD patients
Péran et al., Mvt Disord, 2004
fMRI in PD patients
Activation maps of positive correlations between each condition and the motor deficit
Péran et al., Cortex, 2009
Péran et al., Brain Lang, 2012